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Adolescent testosterone, muscle mass and glucose metabolism: evidence from the 'Children of 1997' birth cohort in Hong Kong.
- Source :
-
Diabetic Medicine . Apr2015, Vol. 32 Issue 4, p505-512. 8p. 5 Charts. - Publication Year :
- 2015
-
Abstract
- Aims Diabetes rates are high in Asia despite relatively low rates of obesity, which might be related to lower muscle mass. Muscle mass plays an important role in glucose metabolism. Peak muscle mass is obtained in late adolescence. We tested the hypothesis that pubertal testosterone is negatively associated with glucose metabolism mediated by muscle mass. Methods Participants aged 15 years (278 boys and 223 girls) were recruited from the Hong Kong's 'Children of 1997' birth cohort in 2012. Multivariable linear regression with multiple imputation and inverse probability weighting was used to examine the adjusted associations of pubertal testosterone with skeletal muscle index, body fat percentage, fasting glucose, insulin and homeostasis model of assessment - insulin resistance. Results Total testosterone was negatively associated with fasting glucose (−0.008, 95% confidence interval −0.015 to −0.002), insulin (−0.43, 95% confidence interval −0.56 to −0.30) and insulin and homeostasis model of assessment - insulin resistance (−0.09, 95% confidence interval −0.12 to −0.06) adjusted for sex, birth weight, highest parental education, mother's place of birth and physical activity. These associations were attenuated by additional adjustment for skeletal mass index or body fat percentage. Conclusions Adolescent glucose metabolism may be influenced by testosterone, perhaps partially via skeletal muscle mass. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTIC use of testosterone
*GLUCOSE metabolism
*OBESITY complications
*CHI-squared test
*CONFIDENCE intervals
*DIABETES
*EPIDEMIOLOGY
*EVALUATION of medical care
*MEDICAL practice
*MUSCLES
*PEDIATRICS
*REGRESSION analysis
*SERIAL publications
*TESTOSTERONE
*DATA analysis
*HUMAN research subjects
*PATIENT selection
*SKELETAL muscle
Subjects
Details
- Language :
- English
- ISSN :
- 07423071
- Volume :
- 32
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Diabetic Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 101556596
- Full Text :
- https://doi.org/10.1111/dme.12602