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Relationship of Skin Autofluorescence to Severity of Retinopathy in Type 2 Diabetes.
- Source :
-
Current Eye Research . Mar2015, Vol. 40 Issue 3, p338-345. 8p. - Publication Year :
- 2015
-
Abstract
- Purpose: To evaluate the relationship between skin autofluorescence (SAF), which reflects the accumulation of advanced glycation end products (AGEs), and the severity of diabetic retinopathy (DR) in patients with type 2 diabetes. Methods: Sixty-seven eyes of 67 patients with type 2 diabetes were enrolled. Sixty-seven age-matched non-diabetic subjects served as controls. Diabetic patients were classified by the severity of their DR: no DR (NDR), non-proliferative DR (NPDR), and proliferative DR (PDR). SAF was measured with an autofluorescence reader. Results: SAF in the diabetes patients was significantly higher than in the controls (median 2.5 (interquartile range 2.3-2.7) and 1.8 (1.6-2.3) arbitrary unit (AU), respectively, p < 0.001). There was a statistically significant increase in SAF along with the increasing severity of DR (from NDR to NPDR: p = 0.034; NPDR to PDR: p < 0.01). Logistic regression analysis revealed that SAF (OR, 17.2; p < 0.05) was an independent factor indicating the presence of PDR. Conclusions: SAF has an independent relationship with PDR in patients with type 2 diabetes. SAF measurement with an autofluorescence reader is a non-invasive way to assess the risk of DR. SAF may, therefore, be a surrogate marker candidate for the non-invasive evaluation of DR. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02713683
- Volume :
- 40
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Current Eye Research
- Publication Type :
- Academic Journal
- Accession number :
- 101577936
- Full Text :
- https://doi.org/10.3109/02713683.2014.918152