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Gamma activity model for treatment-resistant bipolar psychotic mania.
- Source :
-
Indian Journal of Pharmacology . Mar/Apr2015, Vol. 47 Issue 2, p215-218. 4p. - Publication Year :
- 2015
-
Abstract
- Objectives: The objective was to investigate the effect of clozapine on spontaneous gamma activity in treatment-resistant bipolar psychotic mania. Methods: Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30-49 Hz gamma spectral power. Results: Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found. Conclusions: We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CLOZAPINE
*ANTIDEPRESSANTS
*PSYCHOSES
*PATHOLOGICAL psychology
*LITHIUM
Subjects
Details
- Language :
- English
- ISSN :
- 02537613
- Volume :
- 47
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Indian Journal of Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 101794750
- Full Text :
- https://doi.org/10.4103/0253-7613.153434