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Involvement of β-arrestin-2 in modulation of the spinal antinociception induced by μ-opioid receptor agonists in the mouse
- Source :
-
Neuroscience Letters . Jul2003, Vol. 346 Issue 1/2, p13. 4p. - Publication Year :
- 2003
-
Abstract
- Beta-arrestins have been suggested to regulate μ-, δ-, and κ-opioid receptor-mediated responses. In the present study, we examined the effects of pretreatment with β-arrestin-2 antibody on tail-flick inhibition induced by opioid receptor agonists in the mouse spinal cord. Intrathecal (i.t.) pretreatment with β-arrestin-2 antibody potentiated the antinociception induced by i.t.-administered μ-opioid receptor agonists [d-Ala2,NMePhe4,Gly-ol5]enkephalin (DAMGO) and endomorphin-1, but not endomorphin-2, the δ-opioid receptor agonist [d-Ala2]deltorphin II or the κ-opioid receptor agonist U50,488H. The present result suggests that β-arrestin-2 may tonically down-regulate a selected population of μ-opioid receptors activated by endomorphin-1 or DAMGO in the mouse spinal cord. [Copyright &y& Elsevier]
- Subjects :
- *OPIOID receptors
*NOCICEPTORS
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 346
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 10179538
- Full Text :
- https://doi.org/10.1016/S0304-3940(03)00591-3