Towards validating new enzymatic routes for synthetic conversion: 7,10-bis- O-(2,2,2-trichloroethoxycarbonyl)-10-deacetyl baccatin III-ethyl acetate-water (1/1/1).

The title compound, C34H38Cl6O14·C4H8O2·H2O, prepared by the reaction of 10-deacetyl baccatin III with 2,2,2-trichloroethyl chloroformate in pyridine, crystallizes via strong intermolecular hydrogen bonds and noncovalent interactions between 7,10-bis- O-(2,2,2-trichloroethoxycarbonyl)-10-deacetyl baccatin III (7,10-di-Troc-DAB), water and ethyl acetate. A detailed comparison of the molecular conformation with those of related structures is presented. [ABSTRACT FROM AUTHOR]