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Hemoglobin-based oxygen carrier attenuates cerebral damage by improving tissue oxygen preload in a dog model of cardiopulmonary bypass.
- Source :
-
Artificial Cells, Nanomedicine & Biotechnology . Apr2015, Vol. 43 Issue 2, p87-92. 6p. - Publication Year :
- 2015
-
Abstract
- In order to investigate whether hemoglobin-based oxygen carrier (HBOC) attenuates cardiopulmonary bypass (CPB)-induced cerebral damage. Male adult Beagle dogs were randomly divided into sham, control, and HBOC groups. After establishment of CPB model, hearts were arrested for 2 h and reperfused for 2 h. HBOC improved intracerebral O2 tensions and reduced the releases of biomarkers for cerebral damage, including neuron-specific enolase and S100β in both cerebrospinal fluid and serum. Moreover, HBOC attenuated the releases of tumor necrosis factor-α and interleukin-1β after CPB. Therefore, our findings suggest that HBOC could reduce cerebral damage after CPB, which was probably associated with improvement of tissue O2 preload. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 21691401
- Volume :
- 43
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Artificial Cells, Nanomedicine & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 101831551
- Full Text :
- https://doi.org/10.3109/21691401.2014.916716