Prognostic significance of systemic neutrophil and leukocyte alterations in surgically treated endometrial cancer patients: A monoinstitutional study.

Objective The aim of this study was to investigate the prognostic significance of an elevated neutrophil count at the time of the initial diagnosis in patients with surgically treated endometrial cancer. Methods The baseline characteristics and outcome data of patients who were diagnosed with endometrial cancer between January 2000 and December 2010 were collected and retrospectively reviewed. The patients were separated into two groups according to their neutrophil counts. The clinicopathological characteristics and overall survival rates of the two groups were compared. A Cox proportional hazard regression model was used to investigate the prognostic significance of an elevated neutrophil count among patients with surgically treated endometrial cancer. Results An elevated neutrophil count was found to be associated with an advanced clinical stage (P < 0.0001), lymphovascular space involvement (P = 0.0003), cervical involvement (P = 0.0049), the proportion of patients that received adjuvant therapy (P = 0.0020), elevated NLR (P < 0.0001), and treatment failure (P < 0.0001). Multivariate analyses demonstrated that age (hazard ratio (HR) = 2.23, 95% confidence interval (95% CI) = 1.30 to 3.91; P = 0.0035), clinical stage (HR = 4.72, 95% CI = 2.61 to 8.90; P < 0.0001), lymphovascular space involvement (HR = 3.15, 95% CI = 1.60 to 6.68; P = 0.0007), an elevated neutrophil count (HR = 2.76, 95% CI = 1.43 to 5.03; P = 0.0033), and an elevated white blood cell count (HR = 2.79, 95% CI = 1.50 to 4.96; P = 0.0017) were significant predictors of survival. Conclusion The elevated neutrophil or leukocyte counts at the time of the initial diagnosis are independent prognostic factors in patients with surgically treated endometrial cancer. [ABSTRACT FROM AUTHOR]