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Transcriptional regulation of autophagy in RAS-driven cancers.
- Source :
-
Journal of Clinical Investigation . Apr2015, Vol. 125 Issue 4, p1393-1395. 3p. 1 Diagram. - Publication Year :
- 2015
-
Abstract
- RAS-driven cancers exhibit variable dependency on autophagy for survival; however, it is not fully understood how. In this issue of the JCI, Cheong and colleagues demonstrate that RAS-dependent elevation of casein kinase 1α (CK1α) negatively regulates autophagy at the level of autophagy gene transcription. Moreover, combined inhibition of both CK1α and autophagy reduced proliferation of RAS-driven tumors. The results of this study provide insight into the connection between mutant RAS and autophagy, and suggest targeting CK1α as a potential therapeutic strategy to modulate autophagy in RAS-driven cancers. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AUTOPHAGY
*RAS oncogenes
*CASEIN kinase
*TUMORS
*CANCER treatment
Subjects
Details
- Language :
- English
- ISSN :
- 00219738
- Volume :
- 125
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 101915130
- Full Text :
- https://doi.org/10.1172/JCI81504