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Expectorant, antitussive, anti-inflammatory activities and compositional analysis of Aster tataricus.
- Source :
-
Journal of Ethnopharmacology . Apr2015, Vol. 164, p328-333. 6p. - Publication Year :
- 2015
-
Abstract
- Ethnopharmacological relevance The root of Aster tataricus L. f., recorded in all versions of Chinese Pharmacopoeia, is a traditional Chinese medicine with the function of dispelling phlegm and relieving cough for more than 2000 years. This study was designed to evaluate the expectorant, antitussive, and anti-inflammatory activities of the root of A. tataricus and to explore the chemical substances responsible for these activities. Materials and methods The 70% ethanol extract of the root of A. tataricus (RA-70) was divided into three fractions, Fr-0, Fr-50 and Fr-95. They were all orally administrated to the mice to investigate their potential expectorant activities by a tracheal phenol red secretion method. The most effective fraction, together with shionone, was evaluated the expectorant, antitussive and anti-inflammatory activities by the mouse models of phenol red secretion, ammonia-induced cough, and xylene-induced ear swelling. Furthermore, the chemical components of the effective fraction were analyzed and identified by an HPLC-Q-TOF/MS method. Results Treatment with RA-70, Fr-0 and Fr-50 increased the amount of phenol red secretion by 65.3%, 56.5%, and 76.9%, respectively. Fr-50 was chosen for the further investigation and the results showed that Fr-50 at 40, 80 mg/kg significantly enhanced the phenol red secretion of tracheas, increased the latent period and decreased the frequency of cough and inhibited the ear edema in mice. Shionone at 80 mg/kg showed the trend of enhancing sputum secreting, but had no effect on ammonia-induced cough and xylene-induced ear edema. HPLC-Q-TOF/MS analysis indicated that Fr-50 was mainly composed of 12 caffeoylquinic acids (40.8%, in relative peak area), 7 astersaponins (12.0%) and 13 astins/asterinins (pentapeptides, 26.5%). Conclusions The root of A. tataricus has significant expectorant, antitussive and anti-inflammatory effects. Caffeoylquinic acids, astersaponins, and aster peptides, rather than shionone, may be the main constituents responsible for the expectorant and antitussive activities of A. tataricus and act in a synergistic way. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALTERNATIVE medicine
*ANIMAL experimentation
*ANTI-inflammatory agents
*ANTITUSSIVE agents
*BIOPHYSICS
*COUGH
*EDEMA
*EXPECTORANTS
*HIGH performance liquid chromatography
*MASS spectrometry
*RESEARCH methodology
*MEDICINAL plants
*MICE
*PEPTIDES
*PLANT roots
*PHYTOCHEMICALS
*PLANT extracts
*STATISTICAL significance
*DESCRIPTIVE statistics
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 03788741
- Volume :
- 164
- Database :
- Academic Search Index
- Journal :
- Journal of Ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 101919264
- Full Text :
- https://doi.org/10.1016/j.jep.2015.02.036