Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.

Authors :: Dzierba, Carolyn D.
Bi, Yingzhi
Dasgupta, Bireshwar
Hartz, Richard A.
Ahuja, Vijay
Cianchetta, Giovanni
Kumi, Godwin
Dong, Li
Aleem, Saadat
Fink, Cynthia
Garcia, Yudith
Green, Michael
Han, Jianxin
Kwon, Soojin
Qiao, Ying
Wang, Jiancheng
Zhang, Yulian
Liu, Ying
Zipp, Greg
Liang, Zhi
Source :: Bioorganic & Medicinal Chemistry Letters. Apr2015, Vol. 25 Issue 7, p1448-1452. 5p.
Publication Year :: 2015
Abstract: Small molecule modulators of GPR88 activity (agonists, antagonists, or modulators) are of interest as potential agents for the treatment of a variety of psychiatric disorders including schizophrenia. A series of phenylglycinol and phenylamine analogs have been prepared and evaluated for their GPR88 agonist activity and pharmacokinetic (PK) properties. [ABSTRACT FROM AUTHOR]

Subjects :: *G protein coupled receptors
*MENTAL illness treatment
*SCHIZOPHRENIA treatment
*ANILINE synthesis
*PHARMACOKINETICS

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