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Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Apr2015, Vol. 25 Issue 7, p1448-1452. 5p. - Publication Year :
- 2015
-
Abstract
- Small molecule modulators of GPR88 activity (agonists, antagonists, or modulators) are of interest as potential agents for the treatment of a variety of psychiatric disorders including schizophrenia. A series of phenylglycinol and phenylamine analogs have been prepared and evaluated for their GPR88 agonist activity and pharmacokinetic (PK) properties. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 25
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 101925457
- Full Text :
- https://doi.org/10.1016/j.bmcl.2015.01.036