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Lack of Efficacy of Prophylactic Application of Antibiotic-Loaded Bone Cement for Prevention of Infection in Primary Total Knee Arthroplasty: Results of a Meta-Analysis.
- Source :
-
Surgical Infections . Apr2015, Vol. 16 Issue 2, p183-187. 5p. - Publication Year :
- 2015
-
Abstract
- Background: Deep incisional surgical site infection (SSI) is a devastating and costly complication of primary total knee arthroplasty (TKA). The effectiveness of antibiotic-loaded bone cement (ALBC) in preventing these infections remains controversial. Methods: A meta-analysis was conducted to assess the efficacy of ALBC in preventing deep infection in primary TKA after a detailed and systematic search of the PubMed, Embase, CNKI, and Cochrane databases had been performed to identify appropriate comparative trials on the prophylactic use of ALBC in primary TKA. Results: Five comparative trials were included. In total, 3,461 patients (ALBC group) received ALBC, whereas 3,176 patients (non-antibiotic-loaded cement; NALBC group) did not. The incidence of deep incisional SSI in the ALBC group was 1.32% (n=46) whereas the incidence in the NALBC group was 1.89% (n=60), figures which are not significantly different. No adverse events associated with ALBC were reported in any studies. Conclusion: Statistical analysis did not reveal a significantly different incidence of deep or superficial SSI in patients receiving and not receiving antibiotic-loaded cement. The prophylactic application of ALBC thus did not show efficacy in primary TKA. More large-sample studies are required to confirm this finding. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10962964
- Volume :
- 16
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Surgical Infections
- Publication Type :
- Academic Journal
- Accession number :
- 101966290
- Full Text :
- https://doi.org/10.1089/sur.2014.044