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The Accuracy of C-Reactive Protein, Procalcitonin, and s-TREM-1 in the Prediction of Serious Bacterial Infection in Neonates.
- Source :
-
Clinical Pediatrics . May2015, Vol. 54 Issue 5, p439-444. 6p. - Publication Year :
- 2015
-
Abstract
- In this prospective study, we examined the usefulness of C-reactive protein (CRP), soluble triggering receptor expressed on myeloid cells (s-TREM-1), and procalcitonin (PCT), in identifying serious bacterial infection (SBI) among neonates. Infants younger than 3 months with suspected SBI were included and serum concentrations of CRP, PCT, and s-TREM-1 were determined. Results. A total of 112 patients (19 with SBI and 93 with negative cultures) were evaluated. There were no statistical differences between the 2 groups regarding age, presence of fever, and serum concentrations of the different biomarkers. Performance of the different biomarkers were as follows: The sensitivities were 45%, 55%, and 82% for CRP, PCT, and s-TREM-1, respectively, whereas the specificities we 82%, 75%, and 48% for CRP, PCT, and s-TREM-1, respectively. The areas under the receiver operating characteristic curve were 0.6, 0.63, and 0.61, for CRP, PCT, and s-TREM-1, respectively. Conclusions. In real-life pediatric practice, none of the tested biomarkers was sufficiently accurate to serve as a reliable indicator for the identification of SBI in neonates. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00099228
- Volume :
- 54
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Clinical Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 101973518
- Full Text :
- https://doi.org/10.1177/0009922814553435