Glucose-Responsive Polymer Vesicles Templated by α-CD/PEGInclusion Complex.

Polymeric nanoparticles with glucose-responsivenessare of greatinterest in developing a self-regulated drug delivery system. In thiswork, glucose-responsive polymer vesicles were fabricated based onthe complexation between a glucosamine (GA)-containing block copolymerPEG45-b-P(Asp-co-AspGA)and a phenylboronic acid (PBA)-containing block copolymer PEG114-b-P(Asp-co-AspPBA) withα-CD/PEG45inclusion complex as the sacrificial template.The obtained polymer vesicles composed of cross-linked P(Asp-co-AspGA)/P(Asp-co-AspPBA) layer as walland PEG chains as both inner and outer coronas. The vesicular morphologywas observed by transmission electron microscopy (TEM), and the glucose-responsivenesswas investigated by monitoring the variations of hydrodynamic diameter(Dh) and light scattering intensity (LSI)in the polymer vesicle solution with glucose using dynamic light scattering(DLS). Vancomycin as a model drug was encapsulated in the polymervesicles and sugar-triggered drug release was carried out. This kindof polymer vesicle may be a promising candidate for glucose-responsivedrug delivery. [ABSTRACT FROM AUTHOR]