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HYCUD: a computational tool for prediction of effective rotational correlation time in flexible proteins.
- Source :
-
Bioinformatics . 4/1/2015, Vol. 31 Issue 7, p1319-1321. 3p. - Publication Year :
- 2015
-
Abstract
- Motivation: A large fraction of eukaryotic proteins contain unstructured tails or linkers. The presence of flexible regions allows these systems to experience a high level of mobility facilitating their biological function. The complex nature of protein rotation in such flexible modular systems precludes a straightforward application of hydrodynamic methods to calculate their rotational motional properties. We describe the workflow of HYdrodynamic CoUpling of Domains (HYCUD), a program for prediction of effective rotational correlation times in multidomain proteins. The usage of HYCUD is demonstrated by its application to the ribosomal protein L7/L12. Rotational correlation times predicted by HYCUD might be used to detect molecular switch events mediated by disorderorder transitions in interdomain linkers. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENETIC databases
*STRUCTURAL bioinformatics
*RIBOSOMAL proteins
Subjects
Details
- Language :
- English
- ISSN :
- 13674803
- Volume :
- 31
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Bioinformatics
- Publication Type :
- Academic Journal
- Accession number :
- 102125052
- Full Text :
- https://doi.org/10.1093/bioinformatics/btu824