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MAGI3-AKT3 fusion in breast cancer amended.

Authors :
Mosquera, Juan-Miguel
Varma, Sonal
Pauli, Chantal
MacDonald, Theresa Y.
Yashinskie, Jossie J.
Varga, Zsuzsanna
Sboner, Andrea
Moch, Holger
Rubin, Mark A.
Shin, Sandra J.
Source :
Nature. 4/16/2015, Vol. 520 Issue 7547, pE11-E12. 2p. 1 Color Photograph, 1 Chart.
Publication Year :
2015

Abstract

The article discusses a study on the frequency of MAGI3-AKT3 fusion in 236 triple-negative breast cancers (TNBCs) represented in high-density microarrays. TNBC constitutes majority of breast carcinomas and notes that TNBC patients have poor response to conventional breast cancer therapies and experience poor survival. It confirms that MAGI3-AKT3 fusion is not a recurrent event in triple-negative breast cancer that should be acknowledged prior to evaluating targeted therapies in clinical trials.

Details

Language :
English
ISSN :
00280836
Volume :
520
Issue :
7547
Database :
Academic Search Index
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
102125926
Full Text :
https://doi.org/10.1038/nature14265