Critical umbilical artery Doppler abnormalities in early fetal growth restriction and the timing of delivery: an overestimated clinical challenge in daily obstetric practice?

The article presents an explanation of the Trial of Umbilical and Fetal Flow in Europe (TRUFFLE), in response to a comment to a paper on early intrauterine growth restriction (IUGR). Several issues are raised regarding the paper including the morbidity and mortality related to early-onset IUGR, the clinical decision-making relating to delivery, and the terminology and disease definition. The result of the Prospective Observational Trial to Optimize Pediatric Health in IUGR (PORTO) is mentioned.