Back to Search
Start Over
miR-889 promotes proliferation of esophageal squamous cell carcinomas through DAB2IP.
- Source :
-
FEBS Letters . Apr2015, Vol. 589 Issue 10, p1127-1135. 9p. - Publication Year :
- 2015
-
Abstract
- MicroRNAs have been reported to play critical roles in various cancers, but there has been no study on the role of miR-889 in cancers. Here, we report that over-expression of miR-889 leads to rapid proliferation of EC109 and EC9706 cells in vitro and in vivo by inducing cells into S-phase. Using bioinformatics methods, DAB2IP was further confirmed to be a direct target of miR-889. In addition, the expression of DAB2IP, which was negatively correlated with that of miR-889, was significantly associated with clinicopathological features of ESCC patients. In conclusion, miR-889 is an important regulator in ESCC and both miR-889 and DAB2IP may serve as promising biomarkers and therapeutic targets in patients with ESCC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 589
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 102188720
- Full Text :
- https://doi.org/10.1016/j.febslet.2015.03.027