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Protective effect of forsythiaside A on lipopolysaccharide/d-galactosamine-induced liver injury.
- Source :
-
International Immunopharmacology . May2015, Vol. 26 Issue 1, p80-85. 6p. - Publication Year :
- 2015
-
Abstract
- Forsythiaside A, an active constituent isolated from air-dried fruits of Forsythia suspensa , has been reported to have multiple pharmacological activities including anti-inflammatory, anti-oxidant, and antioxidant activities. In the present study, the hepatoprotective effect of forsythiaside A was investigated in lipopolysaccharide (LPS)/ d -galactosamine (GalN)-induced acute liver injury in mice. Mice acute liver injury model was induced by LPS (50 μg/kg)/GalN (800 mg/kg). Forsythiaside A was administrated 1 h prior to LPS/GalN exposure. The results showed that forsythiaside A attenuated hepatic pathological damage, malondialdehyde (MDA) content, and serum ALT, and AST levels induced by LPS/GalN. Moreover, forsythiaside A inhibited NF-κB activation, serum TNF-α and hepatic TNF-α levels induced by LPS/GalN. Furthermore, we found that forsythiaside A up-regulated the expression of Nrf2 and heme oxygenase-1. Our results showed that forsythiaside A protected against LPS/GalN-induced liver injury through activation of Nrf2 and inhibition of NF-κB activation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15675769
- Volume :
- 26
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- International Immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 102260322
- Full Text :
- https://doi.org/10.1016/j.intimp.2015.03.009