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Spinal cord infarction in carriers of methylenetetrahydrofolate reductase-polymorphism-like unique risk factor: report of two cases.
- Source :
-
Spinal Cord . Nov2014 Supplement, Vol. 52, pS8-S10. 3p. - Publication Year :
- 2014
-
Abstract
- Study design:A case report.Objective:To present two cases of spinal cord infarction (SCI) in carriers of the C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism.Setting:Physical Medicine and Rehabilitation Department, Section for Rehabilitation and Traumatology, Hospital Virgen de las Nieves, Granada, Spain.Methods:Two cases are presented, one with SCI at the C7 level American Spinal Injury Association (ASIA) A and one at the C5 level (ASIA A). One patient presented an acute onset of tetraplegia and the other a centromedular syndrome. In both cases the patients were carriers of the MTHFR polymorphism, which is a unique risk factor.Results:Increased blood levels of homocysteine related to mutation of the MTHFR gene increase the risk of a thrombotic episode, triggering the development of SCI. These two cases increase the limited number reported in the recent literature regarding MTHFR polymorphism carriers suffering from thrombotic SCI.Conclusion:MTHFR mutation can be considered a risk factor for thrombotic SCI, but it is not the sole risk factor. We propose that a consensus regarding the inclusion of anticoagulation treatment after confirmation of the diagnosis in these patients is needed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13624393
- Volume :
- 52
- Database :
- Academic Search Index
- Journal :
- Spinal Cord
- Publication Type :
- Academic Journal
- Accession number :
- 102364987
- Full Text :
- https://doi.org/10.1038/sc.2014.129