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Change in renal function following laparoscopic donor nephrectomy using 99 mTc-diethylenetriaminepentaacetic acid scan.
- Source :
-
World Journal of Urology . May2015, Vol. 33 Issue 5, p719-723. 5p. - Publication Year :
- 2015
-
Abstract
- Purpose: We assessed the change in remaining kidney function after laparoscopic donor nephrectomy using serial technetium 99m diethylenetriaminepentaacetic acid (DTPA) scans and investigated the factors affecting the course. Methods: Data from 155 donors were obtained from a prospectively maintained database. All donors underwent consecutive DTPA scans preoperatively and 1 month, 6 months and 1 year postoperatively. We investigated the longitudinal change in renal function after surgery and analyzed parameters to influence the perioperative glomerular filtration rate (GFR) change. Results: The changes in GFR according to the DTPA scan presented significant improvement from 1 month up to 2 years after donation (all p < 0.001). The DTPA-GFR of the remaining kidney increased by 14.8 % to 58.2 ± 10.6 ml/min/1.73 m ( p < 0.001) and by 33.9 % to 78.0 ± 14.0 ml/min/1.73 m at 1 month and 1 year after surgery, respectively ( p < 0.001). Only 21.9 % of donors categorized into chronic kidney disease (CKD) stage 3 or more at 1 year after donation were <60 ml/min/1.73 m according to DTPA-GFR. Multivariate regression analysis revealed that the increase in DTPA-GFR at 1 year was negatively associated with patient age ( p = 0.005), BMI ( p = 0.04) and preoperative DTPA-GFR of remaining kidney ( p = 0.009). Conclusions: The DTPA-GFR of remaining kidney increased steadily for up to 2 years after surgery. Younger donors with lower body mass index and those with lower initial function of the remaining kidney demonstrated a greater increase in DTPA-GFR after nephrectomy. Many of the donors with CKD stage 3 after donation have good renal function according to the results of DTPA-GFR. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07244983
- Volume :
- 33
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- World Journal of Urology
- Publication Type :
- Academic Journal
- Accession number :
- 102427469
- Full Text :
- https://doi.org/10.1007/s00345-014-1408-0