Highly fluorescent perylene dyes with large stokes shifts: synthesis, photophysical properties, and live cell imaging.

Authors :: Qiao, Yanjun
Chen, Jingtian
Yi, Xuegang
Duan, Wenfeng
Gao, Baoxiang
Wu, Yonggang
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. May2015, Vol. 56 Issue 21, p2749-2753. 5p.
Publication Year :: 2015
Abstract: We prepared the peri-linked perylene dyes with π bridges ( PLPDB ) by palladium-mediated coupling reaction. These PLPDB dyes exhibited increased Stokes shifts (55–66 nm) and high fluorescence quantum yields (85–96%) due to cyclic molecular dynamics process. The PEGylated PLPDB dyes were synthesized by attaching PEG pendants to fluorene bridges, and these PEGylated dyes displayed good water solubility and extremely large Stokes shifts (112 nm) in water. The cells incubated with the PEGylated PLPDB dyes showed over 85% cell viability, indicating good cytocompatibility. Live cells image indicates that the PEGylated PLPDB dyes can be efficiently internalized and accumulated by live cells. [ABSTRACT FROM AUTHOR]

Subjects :: *FLUORESCENT dyes
*PERYLENE
*CHEMICAL synthesis
*CELL imaging
*BENZANTHRACENES

Language :: English
ISSN :: 00404039
Volume :: 56
Issue :: 21
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 102454792
Full Text :: https://doi.org/10.1016/j.tetlet.2015.04.026

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