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The Nature’s Clever Trick for Making Cyclic Dinucleotide.
- Source :
-
Structure . May2015, Vol. 23 Issue 5, p801-802. 2p. - Publication Year :
- 2015
-
Abstract
- Ever since their initial discovery few years ago, cyclic dinucleotides (cDNs), their biosynthesis, and their biological function have been in focus of intense research efforts. In this issue, Kato et al. (2015) present strong evidence that the key enzyme in cDN biosynthesis, DncV, is poised on a tipping point such that, given a nudge, the enzyme, can link the nucleotides into a distinct cyclic loop, leading to a specific innate immune response. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DINUCLEOTIDES
*IMMUNE response
*NATURAL immunity
*NUCLEOTIDES
*BIOSYNTHESIS
Subjects
Details
- Language :
- English
- ISSN :
- 09692126
- Volume :
- 23
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Structure
- Publication Type :
- Academic Journal
- Accession number :
- 102462080
- Full Text :
- https://doi.org/10.1016/j.str.2015.04.011