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Solubility of Ketoconazole in Ethanol + Water Mixtures at Various Temperatures.
- Source :
-
Chemical Engineering Communications . Sep2015, Vol. 202 Issue 9, p1211-1215. 5p. 1 Chart, 3 Graphs. - Publication Year :
- 2015
-
Abstract
- Ketoconazole is an important drug with low water solubility. Its low aqueous solubility could be increased using various methods such as by the addition of a pharmaceutical cosolvent. The solubility of ketoconazole in ethanol + water mixtures at 293.2, 298.2, 303.2, and 308.2 K were determined, and the results showed that the addition of ethanol increased the solubility and the maximum value was obtained at 80% of ethanol. The generated data were mathematically represented using the Jouyban–Acree model within an acceptable accuracy. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00986445
- Volume :
- 202
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Chemical Engineering Communications
- Publication Type :
- Academic Journal
- Accession number :
- 102644144
- Full Text :
- https://doi.org/10.1080/00986445.2014.912636