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P-selectin Plasma Levels and Genetic Variant AssociatedWith Diabetic Retinopathy in African Americans.
- Source :
-
American Journal of Ophthalmology . Jun2015, Vol. 159 Issue 6, following p1152-1160. 11p. - Publication Year :
- 2015
-
Abstract
- PURPOSE: To report the prevalence and risk factors for retinopathy in African Americans with impaired fasting glucose (IFG) and type 2 diabetes in the Jackson Heart Study and to determine if P-selectin plasma levels are independently associated with retinopathy in this population. DESIGN: Prospective, cross-sectional observational study. METHODS: SETTING: Community-based epidemiologic study. STUDY POPULATION: Total of 629 patients with type 2 diabetes and 266 participants with impaired fasting glucose. OBSERVATION PROCEDURES: Bilateral, 7-field fundus photographs were scored by masked readers for diabetic retinopathy (DR) level. Covariate data including P-selectin plasma levels and genotypes were collected in a standardized fashion. MAIN OUTCOME MEASURES: Association between risk factors, including P-selectin plasma levels and genotypes, and retinopathy. RESULTS: The prevalences of any retinopathy among participants with IFG and type 2 diabetes were 9.4% and 32.4%, respectively. Among those with type 2 diabetes, in multivariate models adjusted for age, sex, and other traditional risk factors, higher P-selectin levels were associated with any DR (odds ratio = 1.11, 95% confidence interval=1.02-1.21, P=.02) and proliferative DR (odds ratio=1.23, 95% confidence interval= 1.03-1.46, P=.02). To further investigate the relationship between P-selectin and DR, we examined the association between P-selectin genotype and DR. Minor allele homozygotes for the variant rs6128 were less likely to develop DR (P after Bonferroni correction = 0.03). CONCLUSIONS: Both serologic and genetic data show an association between P-selectin and DR in the Jackson Heart Study. If confirmed in other studies, this association may provide insight into the pathogenesis of retinopathy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00029394
- Volume :
- 159
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- American Journal of Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 102698093
- Full Text :
- https://doi.org/10.1016/j.ajo.2015.03.008