Antifebrile Effect of Bupleurum Injection on LPS-induced Fever Model Rats.

[Objective] To study antifebrile effect of bupleurum injection on male SD model rats with LPS-induced fever. [Methods] Febrile rats model wa modeled by intraperitoneal injection of LP (100 μg/kg). We injected rats with bupleurum injection of different concentrations, 5.00, 2.50 ad 1.25 mL/kg, respectively. Body temperatures of rats in each group were recorded at 0. 5, 1.0, 1.5, 2. 0, 2. 5, 3.0, 3.5, 4.0, 4. 5, 5.0, 5.5, 6.0, 6.5, 7.0 and 8. 0 h. With the data, we made a drawing of average heating curves and explored effects of bupleurum injection on body temperatures of febrile model rats. [Results] After intraperitoneal injection of LPS (100 μ/kg), rats in model group shoAved obvious three-phrase heat. 4 hours ater building the model, peak value (1.69 °C ) of body temperature rise appeared. Intramuscular injection of bupleurum injection (5.00, 2.50 ad 1.25 mL/kg) could significatly lower body temperatures of above-mentioned febrile model rats ad it's lasted for 7 to 8 hours. The average values of temperature rise at various time points revealed that antifebrile effect of bupleurum injection had a good dose-dependence. [Conclusions] Bupleurum injection had strong antifebrile effect on LP-induced febrile model rats and the antifebrile effect had a good dose-dependence. [ABSTRACT FROM AUTHOR]