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Yinchenhao decoction in the treatment of cholestasis: A systematic review and meta-analysis.
- Source :
-
Journal of Ethnopharmacology . Jun2015, Vol. 168, p208-216. 9p. - Publication Year :
- 2015
-
Abstract
- Ethnopharmacological relevance Yinchenhao decoction, a well-known Chinese herbal formula, has been widely used in Chinese Medicine for thousands of years. However, no systematic review of Yinchenhao decoction in treating cholestasis has been completed. This study aims to evaluate the efficacy and safety of the Yinchenhao decoction in treating cholestasis. Materials and methods The major databases (PubMed, Embase, Cochrane Library, Chinese Biomedical Database, Wanfang database, VIP medicine information system and China National Knowledge Infrastructure) were searched from the databases׳ inception through November 2014. Randomized controlled trials (RCTs) of Yinchenhao decoction reported in publications for treatment of cholestasis were extracted by two reviewers. The RCTs examined included total efficacy rate and biochemical indices including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and direct bilirubin (DBIL). The Cochrane tool was applied to assess the risk of bias of the trials. The main outcomes of the trials were analyzed using Review Manager 5.3 software. The odds ratio (OR) or mean difference (MD) with a 95% confidence interval (CI) was used to measure the effect. Results Among the 698 studies identified in the literature search, 15 studies involving 1405 subjects with cholestasis were included in the analysis. Yinchenhao decoction demonstrated efficacy in cholestasis treatment whether in a combined application or not. Additionally, the decoction significantly reduced the elevated levels of cholestasis serum markers, such as ALT, AST, TBIL and DBIL, with a significant difference observed in short and long curative time periods. Remarkably, Yinchenhao decoction displayed a significant efficacy in treating the long-term disease. Conclusion No serious adverse event was reported. This meta-analysis provides evidence that Yinchenhao decoction is an effective and safe treatment for cholestasis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHOLESTASIS
*ALTERNATIVE medicine
*ASPARTATE aminotransferase
*BILIRUBIN
*CONFIDENCE intervals
*HERBAL medicine
*MEDICAL databases
*INFORMATION storage & retrieval systems
*MEDICAL information storage & retrieval systems
*CHINESE medicine
*MEDLINE
*META-analysis
*ONLINE information services
*SYSTEMATIC reviews
*EVIDENCE-based medicine
*PROFESSIONAL practice
*STATISTICAL significance
*ALANINE aminotransferase
*RANDOMIZED controlled trials
*TREATMENT effectiveness
*RESEARCH bias
*DISEASE duration
*DATA analysis software
*DESCRIPTIVE statistics
*ODDS ratio
*EVALUATION
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 03788741
- Volume :
- 168
- Database :
- Academic Search Index
- Journal :
- Journal of Ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 102785475
- Full Text :
- https://doi.org/10.1016/j.jep.2015.03.058