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Simple and Efficient One-Step Synthesis of a Highly Enantioselective Catalyst 3,3′-Di(pyrrolidinylmethyl)-H 8 BINOL.
- Source :
-
Synthetic Communications . 2015, Vol. 45 Issue 13, p1541-1545. 5p. - Publication Year :
- 2015
-
Abstract
- A concise one-step synthetic method was developed to prepare (S)-3,3′-di(pyrrolidinylmethyl)-H8BINOL via Mannich-type reaction. Under the optimal reaction conditions, the yield reached 83% (by recrystallization) and 93% (by column chromatography). This new procedure has reduced the molar ratio of pyrrolidine/paraformaldehyde/(S)-H8BINOL from 58:58:1 to 3:3:1, which simplified the previously reported two-step reaction to a one-step reaction with no need for laborious operations such as cooling and solvent degassing, and avoided discharging a large amount of dioxane-containing waste water. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00397911
- Volume :
- 45
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Synthetic Communications
- Publication Type :
- Academic Journal
- Accession number :
- 102809221
- Full Text :
- https://doi.org/10.1080/00397911.2015.1030032