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Evaluation of Regional Cerebral Blood Flow in Alzheimer's Disease Patients with Subclinical Hypothyroidism.
- Source :
-
Dementia & Geriatric Cognitive Disorders . May2015, Vol. 39 Issue 5/6, p360-367. 8p. 1 Diagram, 3 Charts. - Publication Year :
- 2015
-
Abstract
- Background: This study examined regional cerebral blood flow (rCBF) in Alzheimer's disease (AD) patients with and without subclinical hypothyroidism (SCH). Methods: Eleven AD patients with SCH and 141 AD patients without SCH underwent brain perfusion single photon emission computed tomography (SPECT). The SPECT data were analyzed by statistical parametric mapping (SPM8) and FineSRT. Results: AD patients with SCH showed a significantly decreased rCBF mainly in the temporal lobe and thalamus, whereas those without SCH showed a significantly decreased rCBF in the parietotemporal lobe and cingulate gyrus as well as the frontal lobe. Conclusion: Our findings suggest that SCH may affect cerebral perfusion in regions associated with the memory function. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALZHEIMER'S disease diagnosis
*HYPOTHYROIDISM diagnosis
*ACADEMIC medical centers
*AGE factors in disease
*ALZHEIMER'S disease
*BRAIN
*BRAIN mapping
*CEREBRAL circulation
*CHI-squared test
*COGNITION
*COMPARATIVE studies
*HYPOTHYROIDISM
*NEUROPSYCHOLOGICAL tests
*MEMORY
*PERFUSION
*PROBABILITY theory
*RADIONUCLIDE imaging
*THYROID gland function tests
*THYROID hormones
*QUANTITATIVE research
*SINGLE-photon emission computed tomography
*CASE-control method
*DESCRIPTIVE statistics
*MANN Whitney U Test
*DISEASE complications
*OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 14208008
- Volume :
- 39
- Issue :
- 5/6
- Database :
- Academic Search Index
- Journal :
- Dementia & Geriatric Cognitive Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 102814991
- Full Text :
- https://doi.org/10.1159/000375298