Highly sensitive chiral sensing by calix[4]arene-modified silver nanoparticles via dynamic light scattering.

The reasonable chiral discrimination has been achieved using silver nanoparticles technique while improving the sensitivity of chiral recognition is essential and remains a challenging task. Dynamic light scattering (DLS), is expected to be a feasible method for improving the sensitivity of analyte discrimination. In this article, by capping Ag NPs with a novel chiral R-mandelic acid-derived calix[4]arene (R-MAC4), the intriguing optical and other properties of the structures can be modified via self-assembly. A method of dynamic light scattering (DLS) was used to recognize the N-Fmoc- d/l -aspartic acid ( d/l -FAA). Using this dynamic light-scattering technique, the detection sensitivity was improved almost 500-fold, with detection limit of 5.0 × 10 −8 M, compared with Ag NPs methods. [ABSTRACT FROM AUTHOR]