Back to Search
Start Over
Monodisperse water-soluble -Fe2O3/polyvinylpyrrolidone nanoparticles for a magnetic resonance imaging contrast agent.
- Source :
-
Materials Research Innovations . May2015 Supplement s3, Vol. 19, pS58-S62. 5p. - Publication Year :
- 2015
-
Abstract
- Water-soluble γ-Fe2O3/polyvinylpyrrolidone (PVP) nanoparticles were obtained by transferring oleic acid (OA) coated iron-oxide nanocrystals from hexane to water. The particle size of the γ-Fe2O3/PVP nanoparticles with excellent monodispersity is about 14 nm. Fourier transform-infrared (FT-IR) spectroscopy and X-ray photoelectron spectroscopy (XPS) results indicate that PVP anchors on the γ-Fe2O3 nanoparticles through its carbonyl group and provided sufficient hydrophilicity. The maghemite content in the γ-Fe2O3/PVP nanoparticles was about 81 wt-%. The saturation magnetisation of the superparamagnetic γ-Fe2O3/PVP nanoparticles is 57·7 emu g− 1 at 295 K. For in vivo magnetic resonance imaging (MRI) studies, the γ-Fe2O3/PVP nanoparticles can be guided to the target area by a permanent magnet and show negative contrast enhancement on the target area of laboratory mice. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14328917
- Volume :
- 19
- Database :
- Academic Search Index
- Journal :
- Materials Research Innovations
- Publication Type :
- Academic Journal
- Accession number :
- 102883747
- Full Text :
- https://doi.org/10.1179/1432891715Z.0000000001428