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Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma.

Authors :
KU JUNG KWON
SEUNGHEE BAE
KARAM KIM
IN SOOK AN
KYU JOONG AHN
SUNGKWAN AN
HWA JUN CHA
Source :
Molecular Medicine Reports. 2014, Vol. 10 Issue 1, p503-507. 5p.
Publication Year :
2014

Abstract

Melanogenesis is the process of generating pigmentation via melanin synthesis and delivery. Three key enzymes, tyrosinase, tyrosinase-related protein 1 (TRP1) and TRP2, metabolize melanin from L-tyrosine. Melanin synthesizing enzymes are regulated by microphthalmia-associated transcription factor (MITF). The titrated extract of Centella asiatica (TECA) contains the major components asiatic acid, asiaticoside and madecassic acid. The present study revealed that TECA reduces the melanin content in melanocytes. Moreover, the asiaticoside contained in TECA modulated melanogenesis by inhibiting tyrosinase mRNA expression. The decrease in tyrosinase mRNA levels was mediated through MITF. Uniquely, asiaticoside inhibited MITF by decreasing its DNA binding affinity. In conclusion, the results of the present study indicate that asiaticoside treatment may have beneficial effects in hyperpigmentation diseases or for skin whitening. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17912997
Volume :
10
Issue :
1
Database :
Academic Search Index
Journal :
Molecular Medicine Reports
Publication Type :
Academic Journal
Accession number :
102903094
Full Text :
https://doi.org/10.3892/mmr.2014.2159