Efficient synthesis of 3-aryl-1H-indazol-5-amine by Pd-catalyzed Suzuki–Miyaura cross-coupling reaction under microwave-assisted conditions.

Various 3-aryl-1 H -indazol-5-amine derivatives were synthesized by Pd-catalyzed Suzuki–Miyaura cross-coupling reaction of ( NH ) free 3-bromo-indazol-5-amine with arylboronic acids under microwave-assisted conditions. The coupling reaction can be carried out under the conditions with dioxane/H 2 O as solvent, Pd(OAc) 2 and RuPhos as catalyst system, and K 3 PO 4 as a base in good to excellent yields. [ABSTRACT FROM AUTHOR]