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Synthesis of 2-methyl-1,5-dinitro-3- and 2-methyl-1,3-dinitro-5-(trifluoromethyl)benzenes and their transformation into 6-nitro-4-(trifluoromethyl)- and 4-nitro-6-(trifluoromethyl)-1H-indoles.
- Source :
-
Journal of Fluorine Chemistry . Jul2015, Vol. 175, p176-179. 4p. - Publication Year :
- 2015
-
Abstract
- A facile two-step synthesis of 2-methyl-1,5-dinitro-3- and 2-methyl-1,3-dinitro-5-(trifluoromethyl)benzenes is described. The first step is the nitration of otho- and para -methylbenzoic acids to furnish the corresponding dinitroacids. The dinitroacids then react with sulfur tetrafluoride to provide the corresponding trifluoromethylated products. The latter are easily transformed into 6-nitro-4-(trifluoromethyl)- and 4-nitro-6-(trifluoromethyl)-1 H -indoles by applying the Batcho–Leimgruber synthetic protocol. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221139
- Volume :
- 175
- Database :
- Academic Search Index
- Journal :
- Journal of Fluorine Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 102979901
- Full Text :
- https://doi.org/10.1016/j.jfluchem.2015.04.015