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Decreased expression of microRNA-124 is an independent unfavorable prognostic factor for patients with breast cancer.
- Source :
-
Diagnostic Pathology . 5/1/2015, Vol. 10 Issue 1, p1-5. 5p. - Publication Year :
- 2015
-
Abstract
- Background: MicroRNA-124 (miR-124) has been reported to be downregulated in breast cancer. However, its clinical significance and prognostic value in breast cancer have not been extensively studied. Methods: The tissue expression levels of miR-124 were measured using quantitative real-time PCR in 133 breast cancer patients. The correlation between the miR-124 levels and the clinicopathological factors of the patients was also analyzed. Survival and Cox proportional-hazards regression analyses were performed to determine the correlation between miR-124 expression levels and prognosis in the patients. Results: Quantitative real-time PCR analysis showed that miR-124 had lower expression in breast cancer specimens than that in matched adjacent normal breast tissues (0.39 ± 0.16 vs. 1.00 ± 0.39; P < 0.05). Low miR-124 expression level was significantly associated with advanced TNM stage (P = 0.011), lymph node metastasis (P = 0.012), and poorer pathological differentiation (P = 0.023). A significant difference was found that breast cancer patients with low miR-124 expression level had distinctly shorter overall survival than patients with high miR-124 expression level (63.8% vs. 35.2%, P = 0.03). Furthermore, multivariate analysis of the prognosis factors with a Cox proportional hazards model confirmed that low miR-124 expression was a significant independent predictor of poor survival in breast cancer (HR = 3.16, 95% CI: 1.79-9.13, P = 0.017). Conclusion: These findings proved that the decreased expression of miR-124 might be associated with tumor progression and poor prognosis in patients with breast cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BREAST cancer
*MICRORNA
*GENE expression
*CANCER cells
*METASTASIS
Subjects
Details
- Language :
- English
- ISSN :
- 17461596
- Volume :
- 10
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Diagnostic Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 102991456
- Full Text :
- https://doi.org/10.1186/s13000-015-0257-5