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Weak D Type 4.2.2 (DAR1.2) in an African child: Serology and molecular characterization.

Weak D Type 4.2.2 (DAR1.2) in an African child: Serology and molecular characterization.

Authors :
Orlando, Nicoletta
Putzulu, Rossana
Massini, Giuseppina
Scavone, Fernando
Piccirillo, Nicola
Maresca, Maddalena
Zini, Gina
Teofili, Luciana
Source :
Transfusion & Apheresis Science. Apr2015, Vol. 52 Issue 2, p217-219. 3p.
Publication Year :
2015

Abstract

The weak D phenotype is represented by a group of RHD genotypes that code for alterated RhD proteins associated with a reduced RhD expression on red blood cell. By routine serology, some partial D variants are likely to be missed. In this report we describe the case of a three-year-old Black African child with a “unclear” reaction with monoclonal anti-D. We analyzed the blood sample of the child with different methods to conclude that it is a case of DAR 1.2 (weak D 4.2.2) and that it must be transfused with D negative erithrocytes. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14730502
Volume :
52
Issue :
2
Database :
Academic Search Index
Journal :
Transfusion & Apheresis Science
Publication Type :
Academic Journal
Accession number :
103055107
Full Text :
https://doi.org/10.1016/j.transci.2014.12.020