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A novel multiple soaking temperature (MST) method to prepare polylactic acid foams with bi-modal open-pore structure and their potential in tissue engineering applications.
- Source :
-
Journal of Supercritical Fluids . Aug2015, Vol. 103, p28-37. 10p. - Publication Year :
- 2015
-
Abstract
- Bi-modal pore structures were obtained by stepwise depressurization in batch foaming method. In this study, a novel method was developed to produce polylactic acid (PLA) foam with bi-modal pore structure by using multiple soaking temperature (MST) method based on one-step pressure release. The effects of soaking time and temperatures on the formation of bi-modal pore structure were investigated in detail. The formation of macro pores was attributed to the synergistic effect of the supercritical carbon dioxide (SC-CO 2 ) aggregation and the depressurization process. Moreover, bi-modal open-pore structures could be obtained at certain processing conditions. The PLA foams achieved porosity and open pore content as high as 87.9% and 82.4%, with average macro and micro pore size of 150 μm and 8 μm, respectively. The biocompatibility of the PLA open-pore foams was verified by 3T3 fibroblast cell culture. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08968446
- Volume :
- 103
- Database :
- Academic Search Index
- Journal :
- Journal of Supercritical Fluids
- Publication Type :
- Academic Journal
- Accession number :
- 103055277
- Full Text :
- https://doi.org/10.1016/j.supflu.2015.04.019