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A novel multiple soaking temperature (MST) method to prepare polylactic acid foams with bi-modal open-pore structure and their potential in tissue engineering applications.

Authors :
Huang, Jiang-Nan
Jing, Xin
Geng, Li-Hong
Chen, Bin-Yi
Mi, Hao-Yang
Peng, Xiang-Fang
Source :
Journal of Supercritical Fluids. Aug2015, Vol. 103, p28-37. 10p.
Publication Year :
2015

Abstract

Bi-modal pore structures were obtained by stepwise depressurization in batch foaming method. In this study, a novel method was developed to produce polylactic acid (PLA) foam with bi-modal pore structure by using multiple soaking temperature (MST) method based on one-step pressure release. The effects of soaking time and temperatures on the formation of bi-modal pore structure were investigated in detail. The formation of macro pores was attributed to the synergistic effect of the supercritical carbon dioxide (SC-CO 2 ) aggregation and the depressurization process. Moreover, bi-modal open-pore structures could be obtained at certain processing conditions. The PLA foams achieved porosity and open pore content as high as 87.9% and 82.4%, with average macro and micro pore size of 150 μm and 8 μm, respectively. The biocompatibility of the PLA open-pore foams was verified by 3T3 fibroblast cell culture. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08968446
Volume :
103
Database :
Academic Search Index
Journal :
Journal of Supercritical Fluids
Publication Type :
Academic Journal
Accession number :
103055277
Full Text :
https://doi.org/10.1016/j.supflu.2015.04.019