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Preparative-scale separation of ethyl esters of diethylenetriaminepentaacetic acid by flash chromatography.
- Source :
-
Journal of Radioanalytical & Nuclear Chemistry . Jul2015, Vol. 305 Issue 1, p329-336. 8p. 1 Diagram, 1 Chart, 4 Graphs. - Publication Year :
- 2015
-
Abstract
- The penta ethyl ester of diethylenetriamine pentaacetic acid (DTPA) can be used as a prodrug for decorporation of radionuclides in the event of an internal radiation incidents with transuranic elements. A C18 chromatography purification method was successfully developed using a step elution profile to isolate 0.5-3 g of the four ethyl esters of DTPA. Less than 11 % of the isolated di-ethyl and tri-ethyl esters of DTPA, and less than 20 % of the tetra-ethyl ester of DTPA, had degraded in phosphate buffered saline over a 168 h period. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02365731
- Volume :
- 305
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Radioanalytical & Nuclear Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 103108400
- Full Text :
- https://doi.org/10.1007/s10967-014-3904-5