Cu(I)-catalyzed synthesis of N-tosyl-4-iminoquinolizines.

Authors :: Chen, Joanna L.
Namirembe, Sheila
Lauchert, Luke T.
Tsougranis, Gregory H.
Isaacs, André K.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jul2015, Vol. 56 Issue 27, p4105-4108. 4p.
Publication Year :: 2015
Abstract: Pyridines were found to be a convenient nucleophile in the copper(I)-catalyzed synthesis of N -tosyl-4-iminoquinolizines from 2-pyridyl compounds. Intramolecular cyclization of an in situ generated ketenimine and a tethered pyridine, followed by a base-promoted oxidation, affords the desired products in moderate to good yields under mild reaction conditions. [ABSTRACT FROM AUTHOR]

Subjects :: *COPPER catalysts
*QUINOLIZINES
*HETEROCYCLIC compounds synthesis
*PYRIDINE
*NUCLEOPHILES
*RING formation (Chemistry)
*INTERMOLECULAR interactions

Language :: English
ISSN :: 00404039
Volume :: 56
Issue :: 27
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 103116775
Full Text :: https://doi.org/10.1016/j.tetlet.2015.05.030