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Sesquiterpenes from the fruits of Illicium jiadifengpi and their anti-hepatitis B virus activities.
- Source :
-
Fitoterapia . Jul2015, Vol. 104, p41-44. 4p. - Publication Year :
- 2015
-
Abstract
- Two new compounds, 2 S -hydroxyl-jiadifenolide ( 1 ) and jiadifenlactone acid ( 2 ), and eight known compounds were isolated from the fruits of Illicium jiadifengpi . Their structures were analysed using several spectroscopic techniques, including 1D-, 2D-NMR and HR-ESI-MS experiments. The anti-hepatitis B virus (HBV) activities of the isolates were evaluated via HBV transfection of the Hep G2.2.15 cell line. The inhibitory rates of the most active compounds, compounds 4 and 5, on the HBeAg and HBsAg expression were 28.85 ± 3.15% and 17.53 ± 1.81% and 37.93 ± 2.74% and 23.47 ± 9.52% at concentrations of 64.94 μM and 61.35 μM, respectively. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEPATITIS B prevention
*ALTERNATIVE medicine
*ANTIVIRAL agents
*BIOLOGICAL models
*PHYSICAL & theoretical chemistry
*FRUIT
*MASS spectrometry
*MEDICINAL plants
*MICROBIAL sensitivity tests
*NUCLEAR magnetic resonance spectroscopy
*PLANT extracts
*DESCRIPTIVE statistics
*IN vitro studies
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 104
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 103203180
- Full Text :
- https://doi.org/10.1016/j.fitote.2015.05.004