Diastereoselective synthesis of the C29–C41 fragment of karlotoxin 2.

A highly diastereoselective synthesis of the C29–C41 fragment of karlotoxin 2 (KmTx2) is described by employing regio-selective epoxide opening, our own developed domino isomerization followed by C–O and C–C bond formation reaction and chelation-controlled Grignard reaction as key steps. The synthesis involves installation of seven stereocenters present in the C29–C41 fragment of karlotoxin 2. [ABSTRACT FROM AUTHOR]