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Reading the unique DNA methylation landscape of the brain: Non-CpG methylation, hydroxymethylation, and MeCP2.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 6/2/2015, Vol. 112 Issue 22, p6800-6806. 7p. - Publication Year :
- 2015
-
Abstract
- DNA methylation at CpG dinucleotides is an important epigenetic regulator common to virtually all mammalian cell types, but recent evidence indicates that during early postnatal development neuronal genomes also accumulate uniquely high levels of two alternative forms ofmethylation, non-CpG methylation and hydroxymethylation. Here we discuss the distinct landscape of DNA methylation in neurons, how it is established, and how it might affect the binding and function of protein readers of DNAmethylation. We review studies of one critical reader of DNA methylation in the brain, the Rett syndrome protein methyl CpG-binding protein 2 (MeCP2), and discuss how differential binding affinity of MeCP2 for non-CpG and hydroxymethylation may affect the function of this methyl-binding protein in the nervous system. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DNA methylation
*DINUCLEOTIDES
*GENOMES
*NERVOUS system
*CARRIER proteins
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 112
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 103354179
- Full Text :
- https://doi.org/10.1073/pnas.1411269112