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Dosage assessment of valnemulin in pigs based on population pharmacokinetic and Monte Carlo simulation.
- Source :
-
Journal of Veterinary Pharmacology & Therapeutics . Aug2015, Vol. 38 Issue 4, p400-409. 10p. - Publication Year :
- 2015
-
Abstract
- To estimate the valnemulin pharmacokinetic profile in a swine population and to assess a dosage regimen for increasing the likelihood of optimization. This study was, respectively, performed in 22 sows culled by p.o. administration and in 80 growing-finishing pigs by i.v. administration at a single dose of 10 mg/kg to develop a population pharmacokinetic model and Monte Carlo simulation. The relationships among the plasma concentration, dose, and time of valnemulin in pigs were illustrated as C i, v = X0(8.4191 × 10-4 × e−0.2371 t + 1.2788 × 10−5 × e−0.0069 t) after i.v. and C p. o = X0(−8.4964 × 10−4 × e−0.5840 t + 8.4195 × e−0.2371 t + 7.6869 × 10−6 × e−0.0069 t) after p.o. Monte Carlo simulation showed that T> MIC was more than 24 h when a single daily dosage at 13.5 mg/kg BW in pigs was administrated by p.o., and MIC was 0.031 mg/L. It was concluded that the current dosage regimen at 10-12 mg/kg BW led to valnemulin underexposure if the MIC was more than 0.031 mg/L and could increase the risk of treatment failure and/or drug resistance. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01407783
- Volume :
- 38
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Veterinary Pharmacology & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 103382236
- Full Text :
- https://doi.org/10.1111/jvp.12199