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Copper-Catalyzed Oxidative C(spĀ³)-H Functionalization for Facile Synthesis of 1,2,4-Triazoles and 1,3,5-Triazines from Amidines.
- Source :
-
Organic Letters . Jun2015, Vol. 17 Issue 12, p2894-2897. 4p. - Publication Year :
- 2015
-
Abstract
- A facile and versatile catalytic system involving copper catalyst, K3PO4 as the base, and O2 as the oxidant has been developed to enable efficient synthesis of 2,4,6-trisubstituted and 2,6-disubstituted 1,3,5-triazines and 1,3-disubstituted 1,2,4-triazoles from amidines with trialkylamines, DMSO, and DMF as the reaction partners, respectively. This protocol features inexpensive metal catalyst, green oxidant, good functional group tolerance, and high regioselectivity, providing an efficient entry to those products that are challenging to prepare by traditional methods. A single-electron-transfer (SET) mechanism is proposed for these transformations. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COPPER catalysts
*OXIDATIVE stress
*TRIAZINES
*AMIDINES
*CHEMICAL reactions
Subjects
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 17
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 103412402
- Full Text :
- https://doi.org/10.1021/acs.orglett.5b00995