Back to Search
Start Over
Unique Features of Naive CD8+ T Cell Activation by IL-2.
- Source :
-
Journal of Immunology . 12/1/2013, Vol. 191 Issue 11, p5559-5573. 15p. - Publication Year :
- 2013
-
Abstract
- IL-2 has a pervasive influence on the immune system and dictates the survival and differentiation of multiple T cell subsets, including CD4 regulatory T cells, CD4 Th cells, and CD8 memory cells. IL-2 is synthesized by T cells during the early stages of the immune response and promotes T cell expansion and effector cell generation after initial activation via TCR signaling. Based on studies with activated T cell lines maintained in vitro, IL-2 is known to activate multiple signaling pathways that show considerable overlap with the pathways elicited via the TCR. In this paper, we have examined IL-2 signaling under TCR-independent conditions, namely by culturing purified resting naive CD8 T cells with IL-2 in the absence of Ag or APC. Under these conditions, we show in this study that IL-2 elicits a unique pattern of signaling associated with strong lymphocyte-specific protein tyrosine kinase/JAK3-dependent activation of the PI3K/AKT pathway with little or no involvement of STAT5, NF-κB, or the calcineurin/NFAT pathways. Such signaling induces marked proliferation associated with rapid and selective expression of eomesodermin but not T-bet and differentiation into long-lived central memory cells after adoptive transfer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERLEUKIN-2
*T cells
*IMMUNE system
*TYROSINE
*IMMUNOSPECIFICITY
Subjects
Details
- Language :
- English
- ISSN :
- 00221767
- Volume :
- 191
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 103537751
- Full Text :
- https://doi.org/10.4049/jimmunol.1302293