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Cryptic clues as to how water-soluble protein toxins form pores in membranes
- Source :
-
Toxicon . Jul2003, Vol. 42 Issue 1, p1. 6p. - Publication Year :
- 2003
-
Abstract
- Pore-forming protein toxins possess the remarkable property that they can exist either in a stable water-soluble state or as an integral membrane pore. In order to convert from the water-soluble to the membrane state, the toxin must undergo large conformational changes. Recent work on a class of pore-forming toxins that are rich in β-sheet content suggests a common mechanism of membrane insertion may exist despite these toxins possessing very different primary, tertiary and quaternary structures. [Copyright &y& Elsevier]
- Subjects :
- *TOXINS
*PROTEINS
*BIOLOGICAL membranes
Subjects
Details
- Language :
- English
- ISSN :
- 00410101
- Volume :
- 42
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Toxicon
- Publication Type :
- Academic Journal
- Accession number :
- 10354684
- Full Text :
- https://doi.org/10.1016/S0041-0101(03)00106-5