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Particulate air pollution and circulating biomarkers among type 2 diabetic mellitus patients: the roles of particle size and time windows of exposure.
- Source :
-
Environmental Research . Jul2015, Vol. 140, p112-118. 7p. - Publication Year :
- 2015
-
Abstract
- Background Short-term associations between size-fractionated particulate matter (PM) air pollution and circulating biomarkers are not well established, especially among diabetes patients. Methods We conducted a longitudinal panel study involving 6 repeated measurements of 12 circulating biomarkers among 35 diabetes patients from April to June, 2013 in Shanghai, China. Real-time number and mass concentrations of PM with multiple size fractions between 0.25 and 10 μm were measured. Linear mixed-effect models were used to explore the associations between size-fractionated PM concentrations and blood biomarkers at different time windows. Results Short-term exposure to PM was significantly associated with elevated levels of 5 biomarkers of inflammation, 3 biomarkers of coagulation and 1 vasoconstrictor. The effects varied considerably by particle size and time windows. Overall, PM with smaller size had stronger associations, and the most significant size fractions were 0.25–0.40 μm. Even 2 h exposure to PM can lead to a significant increase in biomarkers. The effects on biomarkers of inflammation and vasoconstriction were restricted to the first 12 h after exposure, but the effects on coagulation persisted for 24–72 h. For example, an interquartile range increase in 2 h average exposure to PM 0.25–0.40 was associated with 6–20% increase in biomarkers of inflammation, 19–38% in coagulation and 17% in vasoconstriction. PM had a stronger effect among male patients than female patients. Conclusions Our results provided important evidence on the roles of the size and time windows of exposure in the PM-mediated effects on circulating biomarkers of inflammation, coagulation and vasoconstriction in diabetes patients in China. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00139351
- Volume :
- 140
- Database :
- Academic Search Index
- Journal :
- Environmental Research
- Publication Type :
- Academic Journal
- Accession number :
- 103589523
- Full Text :
- https://doi.org/10.1016/j.envres.2015.03.026