Dominant Negative Form of Signal-regulatory Protein-α (SIRPα/SHPS-1) Inhibits Tumor Necrosis Factor-mediated Apoptosis by Activation of NF-κB.

Identifies new genes controlling cell response to tumor necrosis factor (TNF) using the genetic suppressor element (GSE) methodology. Screening of a retroviral library of randomly fragmented normalized cDNA from mouse fibroblasts for GSE capable of protecting NIH3T3 cells from TNF-induced apoptosis; Dependence of the GSE-mediated activation of the NF-kappa-B on the presence of serum.