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β-cell dysfunction in women with previous gestational diabetes is associated with visceral adipose tissue distribution.
- Source :
-
European Journal of Endocrinology . Jul2015, Vol. 173 Issue 1, p63-70. 8p. - Publication Year :
- 2015
-
Abstract
- Context: Glucose intolerance in pregnancy predicts an increased risk of future type 2 diabetes. Objective: The aim of the study was to evaluate glucose metabolism in women with and without gestational diabetes mellitus (GDM) at 5 years follow-up and identify risk factors associated with disturbed glucose metabolism post-partum. Design: This follow-up study included 300 consecutively enrolled women from a previous population-based cohort study. The participants underwent oral glucose tolerance test under pregnancy and in the follow-up study, in addition to dual-energy X-ray absorptiometry in the follow-up study. Results: Fifty-two women (17.7%) were found to have GDM in pregnancy with an odds ratio of 4.8 developing prediabetes 5 years later. b-cell function, but not insulin resistance or sensitivity, was reduced in the follow-up study after adjusting for known risk factors. Furthermore, visceral fat content at follow-up was increased in GDM women compared to non-GDM women, and the b-cell function declined with increasing visceral fat in both groups but was more pronounced in the women with previous GDM. Conclusions: Women with GDM are at increased risk of developing prediabetes and have a decreased b-cell function 5 years post-partum that is associated with increased visceral fat mass. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08044643
- Volume :
- 173
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- European Journal of Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 103679639
- Full Text :
- https://doi.org/10.1530/EJE-15-0153