Efeitos do nitroxinil 34% administrado em ratos (Rattus norvegicus albinus) no perfil hepático e renal.

The nitroxynil has been widely used in the control of Haemonchus contortus in sheep to be very effective. The objective of this study was to evaluate the effects on the hepatic and renal nitroxynil administered to rats (Rattus norvegicus albinos). We used 34 adult rats (Rattus norvegicus albinos), aged 120 and 140 days, and 22 females, divided into two experimental groups: G1 (control) and G2 (treated) and 12 males, divided into 2 groups G3 (control) and G4 (treated). The animals in groups G2 and G4 received nitroxynil 34% in a single dose, 10mg/kg, via subcutaneous and the animals of the control group G1 and G3 received saline by the same route and the same volume of the recommended dose. The FA and ALT of values the control and treated groups were found below the reference levels, the results of urea remained within normal parameters and histopathological evaluation of kidney and liver fragments revealed a pattern of microscopic normality. Results from this study have demonstrated that nitroxinil 34% administered at dose of 10 mg/kg, subcutaneous, in single application in rats, not promoted alteration hepatic and renal profile. [ABSTRACT FROM AUTHOR]