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High Prevalence of Secondary Hypertension and Insulin Resistance in Patients with Refractory Hypertension.
- Source :
-
Blood Pressure . May2003, Vol. 12 Issue 3, p149-154. 6p. - Publication Year :
- 2003
-
Abstract
- Objective: To determine causes of treatment resistance in patients with refractory hypertension, and to estimate the prevalence of true resistant hypertension. Methods: We studied 50 consecutive patients referred with refractory hypertension after exclusion of hypokalemia and stenosis of the renal artery. Ambulatory blood pressure monitoring was performed in all patients to detect white-coat effect. The patients were hospitalized, antihypertensive drugs were withdrawn and a screening for secondary hypertension was performed. In addition, these patients, and a control group of essential hypertensives controlled with three antihypertensive drugs, underwent a OGTT with 75 g of glucose. Results: Primary normokaliemic hyperaldosteronism was diagnosed in seven patients. Two patients had a pheochromocytoma and six had white-coat effect. The 35 remaining patients with true resistant hypertension shown significant differences in serum insulin and HOMA IR when compared with the control group. Conclusions: These findings show that among normokaliemic treatment-resistant hypertension, the presence of hyperaldosteronism and pheochromocitoma is quite high. Moreover, treatment resistance in hypertensive patients appears to be associated with insulin resistance. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYPERTENSION
*INSULIN resistance
*PATIENTS
*DISEASES
Subjects
Details
- Language :
- English
- ISSN :
- 08037051
- Volume :
- 12
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Blood Pressure
- Publication Type :
- Academic Journal
- Accession number :
- 10371630
- Full Text :
- https://doi.org/10.1080/08037050310009950